***Bio-Nano Theranostic Research ***

2024

1. Laxmanan Karthikeyan, Raju Vivek*. Multimodal Biomedical Utility of “smart nanopolymer” Polyaniline. ACS-Chem Rev-2024. (IF=72.087). (Under communication).

2. Kumar Charu Nanthini, Ramar Thangam, Laxmanan Karthikeyan, Babu Rithisa, P. Abdul Rasheed, Sunhong Min, Heemin Kang, Nachimuthu Kannikaparameswari, Raju Vivek*. Transformative Breakthrough in Cancer Phototherapy Utilizing Bioinspired Chemistry of Polydopamine-Based Multifunctional Nanostructures. Coordination Chemistry Reviews, 2024, (IF-20.6). (Under review).

3. Babu Rithisa, Karunanidhi Gowsalya, P Abdul Rasheed, Raju Vivek*. Recent Progress of Smart Mesoporous Silica-Based Nanovaccine for Triggering the Antitumor Immune Responses. Inorganic Chemistry Communications, 2024. (IF-3.5).

4. Karunanidhi Gowsalya, Babu Rithisa, Yuvaraj Haldorai, Krishnamurthy Shanthi, Raju Vivek*. Engineered Photonic Near-Infrared Light Activated Photothermal Theranostic Nanovaccine Induce Targeted Remodeling of Tumor Microenvironment. Nanomedicine: Nanotechnology, Biology, and Medicine, 2024. (IF-5.4).

2023

1. Raju Vivek*. Multimodal Biomedical Utility of “smart nanopolymer” Polyaniline. ACS-Chem Rev-2023 (IF=72.087) (Under communication).

2. Laxmanan Karthikeyan, Babu Rithisa, Raju Vivek*. Dynamic Therapeutic Effect of Targeted Photothermal Nanovaccine Incorporating Toll-like Receptor 7 Agonist Enhanced Cancer Immunotherapy. Journal of Materials Chemistry B, 2023. (IF=7.0).

3. Laxmanan Karthikeyan, Pathath Abdul Rasheed, Yuvaraj Haldorai, Raju Vivek*. Tumor-Targeted Conjugated Polymer Promotes Photothermal Immunogenic Cell Death and Release of TLR-9 Immunostimulant Induced Efficient Cancer Immunotherapy. ACS-Applied Polymer Materials, 2023, 5, 9, 7167–7179. (IF=5.0).

4. Laxmanan Karthikeyan, Vellingiri Yasothamani, Yuvaraj Haldorai, Johnson Retnaraj Samuel Selvan Christyraj, Raju Vivek*. TLR7/8 Agonist Loaded Polypyrrole-Based Theranostic Nanovaccine for Second Near-Infrared Photothermal Immunotherapy of Cancer. ACS-Applied Nano Materials, 2023, 6, 6279−6291. (IF=5.9).

5. Laxmanan Karthikeyan, Shankar Sobhana, Vellingiri Yasothamani, Raju Vivek*. Multifunctional Theranostic Nanomedicines for Cancer Treatment: Progress and Challenges. Biomedical Engineering Advances, 2023, 5, 100082.

6. Shankar Sobhana, Namratha Partha Sarathy, Laxmanan Karthikeyan, K. Shanthi, Raju Vivek*. NIR-Responsive Ultra-small Copper Sulfide Theranostic Nanoparticles for Targeted Photothermal Ablation-Induced Immunogenic Cell Death of Tumor Cells. Nanotheranostics, 2023, 7(1): 41-60.

2022

1. Karunanidhi Gowsalya, Raju Vivek*. Near-Infrared Light-Activated Dual Targeting Effect of Peptide Conjugated Mesoporous Silica Nanocomposite for Efficient Multifunctional Anticancer Therapy. ACS-Applied Nano Materials, 2022. 5, 17105-17122 (IF=5.9).

2. Vellingiri Yasothamani, Raju Vivek*. Targeted NIR-Responsive Theranostic Immuno-Nanomedicine Combined TLR7 agonist with Immune Checkpoint Blockade for Effective Cancer Photothermal Immunotherapy. Journal of Materials Chemistry B, 2022, 10, 6392-6403. (IF=7.571).

3. Laxmanan Karthikeyan, Raju Vivek*. Synergistic Anti-Cancer Effects of NIR- Light Responsive Nanotherapeutics for Chemo-Photothermal Therapy and Photothermal Immunotherapy: A Combined Therapeutic Approach. Advances in Cancer Biology-Metastasis-2022, 4, 100044.

4. A. Vasanthakumara, C. Rejeeth, Raju Vivek, Thondhi Ponraj, K. Jayaramane, S. K. Anandasadagopan, P Vinayaga Moorthi. Design of Bio-Graphene Based Multifunctional Nanocomposites Exhibits Intracellular Drug Delivery in Cervical Cancer Treatment. ACS-Applied Biomaterials-2022, 5, 6, 2956–2964. (IF=4.7).

5. K.V. Kavya, Stella Vargheese, Shruti Shukla, Imran Khan, Debasish Kumar Dey, Vivek K. Bajpai, Kavitha Thangavelu, Raju Vivek, R.T. Rajendra Kumar, Young-Kyu Han, Yun Suk Huh, Yuvaraj Haldorai. A cationic amino acid polymer nanocarrier synthesized in supercritical CO2 for co-delivery of drug and gene to cervical cancer cells: Colloids and Surfaces B: Biointerfaces-2022, 216, 112584. (IF=5.268).

6. S. Shyamsivappan, R. Vivek, T. Suresh, P. Naveen, K. Adhigaman, A. Sundarasamy, S Athimoolam, P S. Mohan. N-(3'-acetyl-8-nitro-2, 3-dihydro-1H, 3'H-spiro [quinoline-4, 2'-[1, 3, 4] thiadiazol]-5'-yl) acetamides Induced Cell death in MCF-7 cells via G2/M Phase Cell Cycle Arrest. New Journal of Chemistry-2022. 46, 2817 (IF=3.925).

2021

1. V. Yasothamni, Laxmanan Karthikeyan, Namritha Partha Sarathy, Raju Vivek*. Targeted Designing of Multimodal Tumor Seeking Nanomedicine for Breast Cancer-Specific Triple-therapeutic Effects. ACS-Applied Biomaterials-2021, 4, 6575−6588. (IF=4.7).

2. Vellingiri Yasothamani, Laxmanan Karthikeyan, Selvaraj Shyamsivappan, Yuvaraj Haldorai, Dayakar Seetha, and Raju Vivek*. Synergistic Effect of Photothermally Targeted NIR-Responsive Nanomedicine-Induced Immunogenic Cell Death for Effective Triple Negative Breast Cancer Therapy. ACS Biomacromolecules-2021, 22, 2472-2490 (IF=6.2).

3. Karunanidhi Gowsalya, Vellingiri Yasothamani, Raju Vivek*. Emerging Indocyanine Green-integrated Nanocarriers for Multimodal Cancer Therapy: A Review. Nanoscale Adv., 2021, 3, 3332-3352. (IF=5.598).

2020

1. Selvaraj Rajesh Kumar, Ramar Thangam, Raju Vivek, Sivasubramanian Srinivasanb and Nagamony Ponpandian. Synergetic effects of thymoquinone-loaded porous PVPylated Fe3O4 nanostructures for efficient pH-dependent drug release and anticancer potential against triple-negative cancer cells. Nanoscale Adv., 2020, 2, 3209-3221. (IF=5.598).

2. Selvaraj Shyamsivappan, Arjunan Saravanan, Raju Vivek, Thangaraj Suresh, Ramasamy Shankar, K. M. Gothandam,  Palathurai Subramaniam Mohan. Novel phenyl and thiophene dispiro indenoquinoxaline pyrrolidine quinolones induced apoptosis via G1/S and G2/M phase cell cycle arrest in MCF-7 cells. New J. Chem., 2020, 44, 15031-15045. (IF=3.591).        

3. Alok Sharma, Chandrababu Rejeeth, Raju Vivek, Varukattu Nipun Babu, Xianting Ding. Novel Green Silver Nanoparticles as Matrix in the Detection of Small Molecules Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDIMS). J Pharm Innov. 2021, 16:715–725. (IF=2.750).

4. S. Shyamsivappan, Raju Vivek, Arjunan Saravanan, Thangaraj Arasakumar, Thangaraj Suresh, Shunmuganarayanan Athimoolam, Palathurai Subramaniam Mohan. A novel 8-nitro quinoline-thiosemicarbazone analogues induces G1/S & G2/M phase cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway. Bioorganic Chemistry, 97-103709 (2020). (IF=5.307).

5. Nipun Babu V, Wan Lin, Raju Vivek, Chandrababu Rejeeth, Shanmugam Sabarathinam, Zhimeng Yao, Hao Zhang. Targeted and Intrinsic activity of HA-Functionalized PEI-Nanoceria as a Nano Reactor in Potential Triple-Negative Breast Cancer Treatment. ACS Applied Bio Materials, 3, 186-196 (2020). (IF=4.7).

6. V. NipunBabu, Raju Vivek, C. Rejeeth, R. Thangam, T. Ponraj, A. Sharma, S. Kannan. Nanostructured pH-Responsive Biocompatible Chitosan Coated Copper Oxide Nanoparticles: A Polymeric Smart Intracellular Delivery System for Doxorubicin in Breast Cancer Cells. Arabian Journal of Chemistry, 13, 2276-2286 (2020). (IF=6.212).

2019

1. S. Shyamsivappan, Raju Vivek, S. Arjunan, A. Thangaraj, S. Gopalan, T. Suresh, R. Shankar, P. S. Mohan. Synthesis and X-ray Study of Dispiro 8-Nitroquinolone Analogues and Their Cytotoxic Properties against Human Cervical Cancer Cells HeLa. Med. Chem. Commun., 2019. (IF=2.342)

2. 2018

3. Raju Vivek, C. Rejeeth, V. Nipunbabu, S. Kannan, et al. Multifunctional nanoparticles for trimodal photodynamic therapy-mediated photothermal and chemotherapeutic effects. Photodiagnosis and Photodynamic Therapy, 23, 244-253 (2018). (IF=3.631)

4. Raju Vivek. Tactics of Breast Cancer Therapeutics and Future Outlooks. J Cancer Biol Res 6, 1120 (2018).

5. Liping Wang*, Raju Vivek*, Guowu Wang, Jin-Ye Wang. Fabrication of Stable and Well Dispersed PANi@PVP Nanocomposite for Effective Photothermal Therapy. ACS-Biomaterial Science & Engineering, 4, 1880-1890 (2018). (IF=5.8) (* equal contribution)

6. Ponraj, Raju Vivek, M. Paulpandi, C. Rejeeth, V. Nipun Babu, K. Vimala, K. Ananad, S. Sivaselvam, A. Vasanthakumar, N. Ponpandian, S. Kannan. Mitochondrial dysfunction induced apoptosis in breast carcinoma cells through pH-dependent intracellular quercetin NDDS of PVPylated-TiO2NPs. Journal Materials Chemistry B, (2018). (IF-7.571).

2017

1. Raju Vivek, Li-Ping Wang, Jin-Ye Wang. Nanostructured Polyaniline: Synthesis and Application for Photothermal Cancer Therapy. Current Applied Polymer Science, 1, 1-9 (2017)

2. C. Rejeeth, Raju Vivek, V. Nipun babu, A. Sharma, X. Dinga, K. Qian. Cancer Nanomedicine: From PDGF Targeted Drug Delivery. Medchemcomm, (2017) (IF=2.608)

3. T. Ponraj M. Paulpandi, Raju Vivek, K. Vimala, S. Kannan. Protein regulation and Apoptotic induction in human breast carcinoma cells (MCF-7) through lectin from G. beauts, International Journal of Biological Macromolecules, 95, 1235–1245 (2017) (IF=8.025)

4. M. Sathuvan,  R. Thangam, M. Gajendiran, Raju  Vivek, S. Balasubramanian, S. Nagaraj, B. Madhan, R. Rengasamy. k-Carrageenan: An effective drug carrier to deliver Curcumin in Cancer cells and to Induce Apoptosis. Carbohydrate Polymers, 160, 184–193 (2017) (IF=10.723)

2016

1. Raju Vivek, Ramar Thangam, Selvaraj Rajesh Kumar, Chandrababu Rejeeth, Srinivasan Sivasubramanian, Savariar Vincent, Dhanaraj Gopi, Soundarapandian Kannan. HER2 Targeted Breast Cancer Therapy with Switchable “Off/On” Multifunctional “Smart” Magnetic Polymer Core-Shell Nanocomposites. ACS-Applied Materials & Interfaces, 8, 2262-2279 (2016) (IF=10.383)

2. C. Rejeeth and Raju Vivek. Comparison of two silica based nonviral gene therapy vectors for breast carcinoma: evaluation of the p53 delivery system in Balb/c mice. Artificial Cells, Nanomedicine, and Biotechnology, 10.1080/21691401.2016.1175443 (2016) (IF=4.462)

3. Guo Wu Wang, Raju Vivek and Jin-Ye Wang. Polyaniline Nanoparticles: Synthesis, Dispersion and Biomedical Applications. Mini-Reviews in Organic Chemistry, 2016, Vol. 13, No. 6 (IF=1.824)

4. C. Murugan, K. Rayappan, R. Thangam, R. Bhanumathi, K. Shanthi, Raju Vivek, R. Thirumurugan, A. Bhattacharyya, S. Sivasubramanian, P. Gunasekaran, and S. Kannan. Combinatorial Nanocarrier Based Drug Delivery Approach for Amalgamation of Anti-Tumor Agents in Breast Cancer Cells-An Improved Nanomedicine Strategies. Nature Scientific Reports, 6, 34053; doi: 10.1038/srep34053 (2016) (IF=4.259)

2015

1. C. Rejeeth, Raju Vivek, and S. Kannan. A novel magnetic drug delivery nanocomplex of cisplatin-conjugated Fe3O4 core and a PEG-functionalized mesoporous silica shell nanocomposite for enhancing drug delivery efficiency of cancers. RSC Advances Communication, 5, 94534-94538 (2015) (IF=3.361)

2. K. Saravanakumar, Raju Vivek, N S Boopathy, Li Yaqian, K. Kathiresan, Jie Chen. Anticancer potential of bioactive 16-methylheptadecanoic acid methyl ester derived from marine Trichoderma. Journal of Applied Biomedicine 13, 199-212 (2015) (IF=1.797)

3. R. Thangam, S. Sundarraj, Raju Vivek, V. Suresh, S. Sivasubramanian, M. Paulpandi, V. Karthick, S. Ragavi, S. Kannan. Theranostic Potentials of Multifunctional Chitosan-Silver-Phycoerythrin Nanocomposites against Triple Negative Breast Cancer Cells. RSC Advances, 5, 12209-12223 (2015) (IF=3.361)

2014

1. Raju Vivek, Ramar Thangam, Varukattu NipunBabu, Chandrababu Rejeeth, Srinivasan Sivasubramanian, Palani Gunasekaran, Krishnasamy Muthuchelian, Soundarapandian Kannan, Multifunctional HER2-Antibody Conjugated Polymeric Nanocarrier Based Drug Delivery System for Multidrug-Resistant Breast Cancer Therapy. ACS-Applied Materials & Interfaces, 6, 6469−6480 (2014) (IF=10.383)

2. Raju Vivek, R. Thangam, V Nipun Babu; T. Ponraj, S Kannan; Oxaliplatin-Chitosan Nanoparticles Induced Apoptotic Signaling Pathway: A "smart" Drug Delivery System for cancer Therapy. International Journal of Biological Macromolecules, 65, 289–297 (2014) (IF=8.025)

3. C. Rejeeth, B. Nataraj, Raju Vivek and M. Sakthivel. Biosynthesis of Silver Nanoscale Particles Using Spirulina platensis Induce Growth-Inhibitory Effect on Human Breast Cancer Cell Line MCF-7, Med Aromat Plants, 3:4 (2014) (IF=1.42)

2013

  3. Raju Vivek, V. Nipun Babu, R. Thangam, K.S. Subramanian, S. Kannan. pH-responsive Drug Delivery of Chitosan Nanoparticles as Tamoxifen Carriers for Effective Anti-Tumour Activity in Breast Cancer. Colloids and Surface B: Interfaces, 111, 117-123 (2013) (IF=5.999)

2012

  2. Raju Vivek, Ramar Thangam, Krishnasamy Muthuchelian, Palani Gunasekaranb, Krishnasamy Kaveri, Soundarapandian Kannan. Green synthesis of silver nanoparticles from Annona squamosa leaf and its in vitro cytotoxic effect on human breast cancer (MCF-7) cells, Process Biochemistry, 47, 2405–2410 (2012) (IF= 4.885)

2011

  1. Raju Vivek, Soundarapandian Kannan, Shanmugam Achiraman, Ramasamy Thirumurugan, Devaraj Sankar Ganesh, Muthukalingan Krishnan. Survivin Deficiency Leads to Imparalization of Cytokinesis in Cancer Cells. Asian Pacific Journal of Cancer Prevention, 12, 1-4 (2011) (IF=2.52)